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Translocation of TRAF6 to CBM complex
Stable Identifier
R-HSA-202472
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Translocation of TRAF6 to CBM complex (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TRAF6, which plays central role in innate immune responses, is implicated as proximal downstream effector of MALT1. TRAF6 is a member of the TRAF proteins. It contains an N-term RING domain, followed by several Zn finger domains and C-term MATH domain. The MALT1 oligomers bind to TRAF6, induce TRAF6 oligomerization and thereby activate the ubiquitin ligase activity of TRAF6 to polyubiquitinate itself and NEMO.
Literature References
PubMed ID
Title
Journal
Year
15125833
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
Deng, L
,
Chen, ZJ
,
Sun, L
,
Xia, ZP
,
Ea, CK
Mol Cell
2004
Participants
Input
MALT1 trimer bound to Bcl10 and CARMA1 trimer [plasma membrane]
(Homo sapiens)
x 3
TRAF6 [cytosol]
(Homo sapiens)
Output
TRAF6 trimer bound to CBM complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Downstream TCR signaling (Homo sapiens)
Orthologous Events
Translocation of TRAF6 to CBM complex (Bos taurus)
Translocation of TRAF6 to CBM complex (Canis familiaris)
Translocation of TRAF6 to CBM complex (Gallus gallus)
Translocation of TRAF6 to CBM complex (Mus musculus)
Translocation of TRAF6 to CBM complex (Rattus norvegicus)
Translocation of TRAF6 to CBM complex (Sus scrofa)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-30)
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