Phosphorylation of CARMA1

Stable Identifier
R-HSA-202437
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Literature References
PubMed ID Title Journal Year
16356853 Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Rueda, D, Thome, M

Immunity 2005
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Thome, M, Weil, R

Trends Immunol 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Active PKC theta bound to DAG [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created