Reactome | Phosphorylation of CARMA1

Phosphorylation of CARMA1

Stable Identifier

R-HSA-202437

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Antigen receptor triggered PKC theta dependent linker phosphorylation of S559 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment (Sommer et al. 2005). PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Literature References

PubMed ID	Title	Journal	Year
16356855	Phosphorylation of the CARMA1 linker controls NF-kappaB activation Sommer, K, Guo, B, Pomerantz, JL, Bandaranayake, AD, Moreno-Garcia, ME, Ovechkina, YL, Rawlings, DJ	Immunity	2005
17468049	Post-translational modifications regulate distinct functions of CARMA1 and BCL10 Thome, M, Weil, R	Trends Immunol	2007
16356853	Phosphorylation of CARMA1: the link(er) to NF-kappaB activation Rueda, D, Thome, M	Immunity	2005