Phosphorylation of CARMA1

Stable Identifier
R-HSA-202437
Type
Reaction
Species
Homo sapiens
Compartment
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Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation.

Literature References
PubMed ID Title Journal Year
17468049 Post-translational modifications regulate distinct functions of CARMA1 and BCL10

Weil, R, Thome, M

Trends Immunol 2007
16356853 Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Rueda, D, Thome, M

Immunity 2005
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of Active PKC theta bound to DAG [plasma membrane]

Orthologous Events
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