Reactome | Translocation of CARMA1 to Plasma membrane

Translocation of CARMA1 to Plasma membrane

Stable Identifier

R-HSA-202394

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Translocation of CARMA1 to Plasma membrane

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CARMA1 and Bcl10 are the possible link between PKC theta and IKK activation. PDK1 is also required for PKC theta mediated activation of IKK. CARMA1 has a N-terminal CARD motif, a coiled coiled region, a linker region, and a MAGUK-typical PDZ, SH3 and a GUK domains. The linker region is proposed to contain a hinge region and a CARD binding domain. CARMA1 exists in an inactive conformation in which the linker region binds to and blocks the accessibility of the CARD motif. CARMA1 is recruited to the plasma membrane by binding to the 'PxxP' motif of membrane bound PDK1 with its SH3 domain.

Literature References

PubMed ID	Title	Journal	Year
15541657	The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling Wang, D, Lin, X	Semin Immunol	2004
17468049	Post-translational modifications regulate distinct functions of CARMA1 and BCL10 Weil, R, Thome, M	Trends Immunol	2007
15122200	CARMA1, BCL-10 and MALT1 in lymphocyte development and activation Thome, M	Nat Rev Immunol	2004