Recruitment of ITK to SLP-76

Stable Identifier
R-HSA-202375
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Recruitment of ITK to SLP-76
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ITK is a member of the Tec protein tyrosine kinase family which forms a complex with SLP-76 after TCR activation. ITK has N-terminal pleckstrin homology (PH) domain, a Tec homology (TH) domain, a proline rich domain, a SH3 domain, an SH2 domain and a C-term kinase domain. The SH2 domain of ITK may interact with Y145 within the N-ter acidic domain of SLP-76 and the SH3 domain of the ITK binds the proline rich region of SLP-76. ITK plays an important role in phosphorylating and activating PLC-gamma-1, leading to the development of second-messenger molecules.

Literature References
PubMed ID Title Journal Year
17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat

Qi, Q, August, A

Sci STKE 2007
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Recruitment of ITK to SLP-76 (Bos taurus)
Recruitment of ITK to SLP-76 (Canis familiaris)
Recruitment of ITK to SLP-76 (Mus musculus)
Recruitment of ITK to SLP-76 (Rattus norvegicus)
Recruitment of ITK to SLP-76 (Sus scrofa)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)