PI3K bound to TRAT1 phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-202365
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
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PI3K enzyme bound to adaptor protein TRIM, uses phosphatidylinositol 4,5-bisphosphate (PIP2) as its substrate and phosphorylates it to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB.
Literature References
PubMed ID Title Journal Year
12660731 The role of PI3K in immune cells

Koyasu, S

Nat Immunol 2003
Participants
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Output
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as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K bound to TRAT [plasma membrane]

Physical Entity
PI3K bound to TRAT [plasma membrane] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Bos taurus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Canis familiaris)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Gallus gallus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Sus scrofa)
Cross References
Rhea
Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
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