Recruitment of PLC-gamma1 to SLP-76

Stable Identifier
R-HSA-202331
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PLC-gamma1 plays an important role in transducing the external signal in to second messengers by hydrolysing PIP2. PLC-gamma1 contains an N-term PH domain, a catalytic domain 'X' followed by two SH2 domains and an SH3 domain, a C-term catalytic domain 'Y' and a C2 domain (Ca++ binding). PLC-gamma1 interacts with both SLP-76 aswell as LAT. It interacts with its SH3 domain to the proline rich sequence of SLP-76. This interaction aids in localizing PLC-gamma1 to the membrane. This recruitment of PLC-gamma1 to LAT and SLP-76 is essential for its TCR induced tyrosine phosphorylation and activation.

Literature References
PubMed ID Title Journal Year
11390650 Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT

Yablonski, D, Kadlecek, T, Weiss, A

Mol Cell Biol 2001
11048639 The mechanism of phospholipase C-gamma1 regulation

Kim, MJ, Kim, E, Ryu, SH, Suh, PG

Exp Mol Med 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!