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Recruitment of PLC-gamma1 to SLP-76
Stable Identifier
R-HSA-202331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Immune System (Homo sapiens)
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TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PLC-gamma1 plays an important role in transducing the external signal in to second messengers by hydrolysing PIP2. PLC-gamma1 contains an N-term PH domain, a catalytic domain 'X' followed by two SH2 domains and an SH3 domain, a C-term catalytic domain 'Y' and a C2 domain (Ca++ binding). PLC-gamma1 interacts with both SLP-76 aswell as LAT. It interacts with its SH3 domain to the proline rich sequence of SLP-76. This interaction aids in localizing PLC-gamma1 to the membrane. This recruitment of PLC-gamma1 to LAT and SLP-76 is essential for its TCR induced tyrosine phosphorylation and activation.
Literature References
PubMed ID
Title
Journal
Year
11048639
The mechanism of phospholipase C-gamma1 regulation
Suh, PG
,
Kim, MJ
,
Kim, E
,
Ryu, SH
Exp Mol Med
2000
11390650
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT
Kadlecek, T
,
Yablonski, D
,
Weiss, A
Mol Cell Biol
2001
Participants
Input
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]
(Homo sapiens)
PLCG1 [cytosol]
(Homo sapiens)
Output
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane]
(Homo sapiens)
Participates
as an event of
Generation of second messenger molecules (Homo sapiens)
Orthologous Events
Recruitment of PLC-gamma1 to SLP-76 (Bos taurus)
Recruitment of PLC-gamma1 to SLP-76 (Canis familiaris)
Recruitment of PLC-gamma1 to SLP-76 (Mus musculus)
Recruitment of PLC-gamma1 to SLP-76 (Rattus norvegicus)
Recruitment of PLC-gamma1 to SLP-76 (Sus scrofa)
Authored
Garapati, P V (2008-01-24)
Rudd, C.E. (2008-01-24)
de Bono, B (2008-01-24)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2007-10-29)
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