Recruitment of Gads to LAT

Stable Identifier
R-HSA-202325
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of Gads to LAT
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Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT.

Literature References
PubMed ID Title Journal Year
11607830 The role of Gads in hematopoietic cell signalling

Liu, SK, McGlade, CJ, Berry, DM

Oncogene 2001
Participants
Input
Output
Participates
as an event of
Orthologous Events
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Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
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