Recruitment of Gads to LAT

Stable Identifier
R-HSA-202325
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Recruitment of Gads to LAT
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT.
Literature References
PubMed ID Title Journal Year
11607830 The role of Gads in hematopoietic cell signalling

Liu, SK, Berry, DM, McGlade, CJ

Oncogene 2001
Participants
Input
Output
Participates
as an event of
Orthologous Events
Recruitment of Gads to LAT (Bos taurus)
Recruitment of Gads to LAT (Canis familiaris)
Recruitment of Gads to LAT (Mus musculus)
Recruitment of Gads to LAT (Rattus norvegicus)
Recruitment of Gads to LAT (Sus scrofa)
Authored
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Garapati, P V  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
Cite Us!