Phosphorylation of PLC-gamma1

Stable Identifier
R-HSA-202248
Type
Reaction
Species
Homo sapiens
Compartment
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Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.

Immunoglobulin superfamily member 2 (IgSF2 or cell surface glycoprotein V7)ligation interferes with T cell activation and IL-2 secretion through a Ca2+ and tyrosine kinase-dependent pathway that inhibits PLC-gamma1 phosphorylation and prevents NF-AT translocation to the nucleus (Soares et al. 1998, 1997).

Literature References
PubMed ID Title Journal Year
11048639 The mechanism of phospholipase C-gamma1 regulation

Suh, PG, Kim, MJ, Kim, E, Ryu, SH

Exp Mol Med 2000
Participants
Participates
Catalyst Activity

protein tyrosine kinase activity of ZAP-70 and ITK tyrosine kinases [plasma membrane]

This event is regulated
Negatively by
Orthologous Events
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