Phosphorylation of PLC-gamma1

Stable Identifier
R-HSA-202248
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Three tyrosine residues at positions 771, 783 and 1254 in PLC-gamma1 have been identified as the sites of receptor tyrosine kinase phosphorylation. Of these Y783 and Y1254 are required for activation of PLC-gamma1. The phosphorylation of the tyrosine residues and the activation of PLC-gamma1 is mediated by both Syk tyrosine kinase ZAP-70 and Tec kinase ITK.

Literature References
PubMed ID Title Journal Year
11048639 The mechanism of phospholipase C-gamma1 regulation

Kim, MJ, Kim, E, Ryu, SH, Suh, PG

Exp Mol Med 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of ZAP-70 and ITK tyrosine kinases [plasma membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created