Reactome | PI3K synthesizes PIP3 downstream of ALK

PI3K synthesizes PIP3 downstream of ALK

Stable Identifier

R-HSA-201510

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PI3K phosphorylates PIP2 to PIP3 downstream of activated ALK, leading to activation of the AKT pathway as assessed by S473 phosphorylation (Bai et al, 2000; Slupianek et al, 2001; Slupianek et al, 2004; Chen et al, 2008). AKT signaling contributes to apoptotic escape and cellular proliferation through regulation of proteins such as CDKN1B/p27, CCND2 and BCL2L11/BIM, among others (Gu et al, 2004; Rassidakis et al, 2005; Marzec et al, 2007; reviewed in Chiarle et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
11110708	Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway Ouyang, T, Morris, SW, Bai, RY, Duyster, J, Miething, C, Peschel, C	Blood	2000
18097461	The anaplastic lymphoma kinase in the pathogenesis of cancer Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C	Nat. Rev. Cancer	2008
15374880	Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma Grammatikakis, I, Claret, FX, Amin, HM, Atwell, C, Rassidakis, GZ, Feretzaki, M, Medeiros, LJ, Lai, R, Lin, Q	Blood	2005
14962911	NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a Griffin, JD, Scheijen, B, Gu, TL, Gilliland, DG, Sternberg, DW, Tothova, Z	Blood	2004
11280786	Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis Morrione, A, Xue, L, Hoser, G, Wasik, MA, Slupianek, A, Nieborowska-Skorska, M, Morris, SW, Majewski, M, Skorski, T	Cancer Res	2001
17353907	Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway Bucki, R, Raghunath, PN, El-Salem, M, Halasa, K, Liu, X, Wlodarski, P, Kasprzycka, M, Marzec, M, Wasik, MA	Oncogene	2007
18923524	Oncogenic mutations of ALK kinase in neuroblastoma Ohira, M, Kikuchi, A, Soda, M, Kato, M, Choi, YL, Nakagawara, A, Hayashi, Y, Wang, L, Ogawa, S, Chen, Y, Sanada, M, Takita, J, Mano, H, Igarashi, T	Nature	2008
15588951	NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner Skorski, T, Slupianek, A	Exp. Hematol.	2004