Reactome | ALK binds ligand pleiotrophin (PTN)

ALK binds ligand pleiotrophin (PTN)

Stable Identifier

R-HSA-201486

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Pleiotrophin (PTN) is a secreted growth factor that induces neurite outgrowth. The receptor tyrosine kinase anaplastic lymphoma kinase (ALK) binds PTN and transduces PTN-mediated signals through RAS, PI3K, PLCG1 and IRS1 (Stoica et al. 2001, Bowden et al. 2002), as well as through GSK3B/CTTNB1 (Yanagisawa et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
12107166	Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase Stoica, GE, Bowden, ET, Wellstein, A	J. Biol. Chem.	2002
11278720	Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin Wellstein, A, Caughey, DJ, Kuo, AH, Karavanov, A, Sunitha, I, Malerczyk, C, Aigner, A, Riegel, AT, Souttou, B, Stoica, GE, Wen, D	J Biol Chem	2001