ALK binds ligand pleiotrophin (PTN)

Stable Identifier
R-HSA-201486
Type
Reaction
Species
Homo sapiens
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Pleiotrophin (PTN) is a secreted growth factor that induces neurite outgrowth. The receptor tyrosine kinase anaplastic lymphoma kinase (ALK) binds PTN and transduces PTN-mediated signals through RAS, PI3K, PLCG1 and IRS1 (Stoica et al. 2001, Bowden et al. 2002), as well as through GSK3B/CTTNB1 (Yanagisawa et al. 2010).

Literature References
PubMed ID Title Journal Year
12107166 Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase

Stoica, GE, Bowden, ET, Wellstein, A

J. Biol. Chem. 2002
11278720 Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

Wellstein, A, Caughey, DJ, Kuo, AH, Karavanov, A, Sunitha, I, Malerczyk, C, Aigner, A, Riegel, AT, Souttou, B, Stoica, GE, Wen, D

J Biol Chem 2001
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