Reactome | p-8Y-FGFR2b P253R dimer [plasma membrane]

p-8Y-FGFR2b P253R dimer [plasma membrane]

Stable Identifier

R-HSA-2011962

Type

Complex

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated FGFR2b P253R dimer

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR2 in disease (Homo sapiens)
      - Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants bind FRS2 (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants bind PLCG1 (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants phosphorylate FRS2 (Homo sapiens)
        
        Activated FGFR2 mutants:FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants phosphorylate PLCG1 (Homo sapiens)
        
        Activated FGFR2 mutants:PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1 (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
        
        FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-FRS2 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - FGFR2 mutant receptor activation (Homo sapiens)
        
        Activated point mutants of FGFR2 (Homo sapiens)
        
        Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
      - p-4Y-PLCG1 dissociates from activated FGFR2 mutants (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
        
        Activated FGFR2 mutants [plasma membrane] (Homo sapiens)
        
        Activated FGFR2b mutants with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)
        
        p-8Y-FGFR2b P253R dimer [plasma membrane] (Homo sapiens)

Participants

components

x 2 p-8Y-FGFR2b P253R [plasma membrane] (Homo sapiens)

Participates

as a member of

p-8Y-FGFR2b dimers with enhanced ligand binding [plasma membrane] (Homo sapiens)

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
bone development disease	DOID:0080006

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