SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix

Stable Identifier
Reaction [transition]
Homo sapiens
CoA(out) <=> CoA(in)
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Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16, providing genetic evidence for a transport activity. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007, Naquet et al. 2020).
Literature References
PubMed ID Title Journal Year
11158296 The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix

Prohl, C, Lill, R, Kispal, G, Diekert, K, Bedekovics, T, Pelzer, W, Kmita, H

Mol Cell Biol 2001
32234503 Regulation of coenzyme A levels by degradation: the 'Ins and Outs'

Kerr, EW, Leonardi, R, Naquet, P, Vickers, SD

Prog Lipid Res 2020
17242360 Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine

Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S

Proc Natl Acad Sci U S A 2007
Catalyst Activity

coenzyme A transmembrane transporter activity of SLC25A16 [mitochondrial inner membrane]

Orthologous Events
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