SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix

Stable Identifier
Reaction [transition]
Homo sapiens
CoA transport across the inner mitochondrial membrane
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007).

Literature References
PubMed ID Title Journal Year
11158296 The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix

Prohl, C, Lill, R, Kispal, G, Diekert, K, Bedekovics, T, Pelzer, W, Kmita, H

Mol Cell Biol 2001
17242360 Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine

Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S

Proc Natl Acad Sci U S A 2007
Catalyst Activity

secondary active transmembrane transporter activity of SLC25A16 [mitochondrial inner membrane]

Orthologous Events
Cite Us!