Reactome | SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix

SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix

Stable Identifier

R-HSA-199216

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

CoA(out) <=> CoA(in)

ReviewStatus

5/5

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SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix

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Graves disease carrier protein (SLC25A16), associated with the inner mitochondrial membrane, mediates the transport of cytosolic coenzyme A (CoA-SH) into the mitochondrial matrix. Evidence for this event is indirect. The protein has sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA-SH and can be rescued by expression of SLC25A16, providing genetic evidence for a transport activity. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001, Leonardi et al. 2007, Naquet et al. 2020).

Literature References

PubMed ID	Title	Journal	Year
11158296	The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix Prohl, C, Pelzer, W, Diekert, K, Kmita, H, Bedekovics, T, Kispal, G, Lill, R	Mol Cell Biol	2001
32234503	Regulation of coenzyme A levels by degradation: the 'Ins and Outs' Naquet, P, Kerr, EW, Vickers, SD, Leonardi, R	Prog Lipid Res	2020
17242360	Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine Leonardi, R, Rock, CO, Jackowski, S, Zhang, YM	Proc Natl Acad Sci U S A	2007