SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

Stable Identifier
R-HSA-199206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pantothenate [extracellular] + 2 Na+ [extracellular] => pantothenate [cytosol] + 2 Na+ [cytosol]
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The plasma membrane-associated transport protein SLC5A6 (SMVT) mediates the uptake of one molecule of pantothenate (PanK) and two sodium ions from the extracellular space to the cytosol. Limited Northern blotting studies suggest that SLC5A6 is widely expressed, and abundant in placenta and small intestine. SLC5A6 may thus play a central role in pantothenate uptake. SLC5A6 also mediates the uptake of biotin and lipoate (Prasad et al. 1999, Wang et al. 1999). PDZ domain-containing protein 11 (PDZD11 aka AIPP1) is a cytosolic protein with a single PDZ domain which can bind to the C-terminal class 1 PDZ binding motif of SLC5A6, resulting in a significant induction of vitamin uptake over that with SLC5A6 alone (Nabokina et al. 2011).

Literature References
PubMed ID Title Journal Year
21183659 Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter

Nabokina, SM, Subramanian, VS, Said, HM

Am. J. Physiol. Gastrointest. Liver Physiol. 2011
10329687 Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.

Wang, H, Huang, W, Fei, YJ, Xia, H, Yang-Feng, TL, Leibach, FH, Devoe, LD, Ganapathy, V, Prasad, PD

J Biol Chem 1999
10334869 Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter

Prasad, PD, Wang, H, Huang, W, Fei, YJ, Leibach, FH, Devoe, LD, Ganapathy, V

Arch Biochem Biophys 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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