Reactome | SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

Stable Identifier

R-HSA-199206

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)

ReviewStatus

5/5

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SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

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The plasma membrane-associated transport protein SLC5A6 (SMVT) mediates the uptake of one molecule of pantothenate (PanK) and two sodium ions from the extracellular space to the cytosol. Limited Northern blotting studies suggest that SLC5A6 is widely expressed, and abundant in placenta and small intestine, consistent with studies in the rat that show a broad tissue distribution (Prasad et al. 1998), consistent with a role for this transporter both for pantothenate uptake from the gut lumen and from the blood into tissues of the body. SLC5A6 also mediates the uptake of biotin and lipoate (Prasad et al. 1999, Wang et al. 1999). PDZ domain-containing protein 11 (PDZD11 aka AIPP1) is a cytosolic protein with a single PDZ domain which can bind to the C-terminal class 1 PDZ binding motif of SLC5A6, resulting in a significant induction of vitamin uptake over that with SLC5A6 alone (Said et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
9516450	Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate Fujita, T, Wang, H, Leibach, FH, Ganapathy, V, Devoe, LD, Prasad, PD, Fei, YJ, Kekuda, R	J Biol Chem	1998
10329687	Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. Wang, H, Leibach, FH, Xia, H, Ganapathy, V, Yang-Feng, TL, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	J Biol Chem	1999
21183659	Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter Said, HM, Nabokina, SM, Subramanian, VS	Am. J. Physiol. Gastrointest. Liver Physiol.	2011
10334869	Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter Wang, H, Leibach, FH, Ganapathy, V, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	Arch Biochem Biophys	1999