Reactome | ICAM1-5 bind Integrin alphaLbeta2 (LFA-1)

ICAM1-5 bind Integrin alphaLbeta2 (LFA-1)

Stable Identifier

R-HSA-199050

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ICAM1-5 bind Integrin alphaLbeta2 (LFA-1)

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Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons. VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.

Literature References

PubMed ID	Title	Journal	Year
8995416	cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1 Mizuno, T, Yoshihara, Y, Inazawa, J, Kagamiyama, H, Mori, K	J. Biol. Chem.	1997
11857637	Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases Yusuf-Makagiansar, H, Anderson, ME, Yakovleva, TV, Murray, JS, Siahaan, TJ	Med Res Rev	2002