NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong.
Strong, RK
Deng, L, Mariuzza, RA
Borrego, F, Kabat, J, Kim, DK, Lieto, L, Maasho, K, Pena, J, Solana, R, Coligan, JE
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