Reactome | NKG2D homodimer interacting with ligands

NKG2D homodimer interacting with ligands

Stable Identifier

R-HSA-198983

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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NKG2D homodimer interacting with ligands

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NKG2D is an activating immunoreceptor. By engaging NKG2D, HlA Class I-like molecules such as MICA, MICB, ULBP1-4 and RAE-1 provide powerful costimulation for NK cells and T-cells and can determine the magnitude and outcome of certain effector functions. NKG2D ligands are upregulated on the surfaces of cells under conditions of stress, for example infection or tumorigenesis, and therefore act as molecular flags to the immune system that something is wrong.

Literature References

PubMed ID	Title	Journal	Year
16737824	Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors Deng, L, Mariuzza, RA	Semin Immunol	2006
11955595	Asymmetric ligand recognition by the activating natural killer cell receptor NKG2D, a symmetric homodimer Strong, RK	Mol Immunol	2002
11858820	Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells Borrego, F, Kabat, J, Kim, DK, Lieto, L, Maasho, K, Pena, J, Solana, R, Coligan, JE	Mol Immunol	2002