Reactome | TCR complex interacts with peptide antigen-presenting MHC Class I

TCR complex interacts with peptide antigen-presenting MHC Class I

Stable Identifier

R-HSA-198955

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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TCR complex interacts with peptide antigen-presenting MHC Class I

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T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.

Literature References

PubMed ID	Title	Journal	Year
15136729	Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3 Kjer-Nielsen, L, Dunstone, MA, Kostenko, L, Ely, LK, Beddoe, T, Mifsud, NA, Purcell, AW, Brooks, AG, McCluskey, J, Rossjohn, J	Proc Natl Acad Sci U S A	2004
16551255	How TCRs bind MHCs, peptides, and coreceptors Rudolph, MG, Stanfield, RL, Wilson, IA	Annu Rev Immunol	2006
15534202	Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment Arnett, KL, Harrison, SC, Wiley, DC	Proc Natl Acad Sci U S A	2004