TCR complex interacts with peptide antigen-presenting MHC Class I

Stable Identifier
Reaction [binding]
Homo sapiens
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T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.
Literature References
PubMed ID Title Journal Year
15136729 Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3

Beddoe, T, Purcell, AW, Dunstone, MA, McCluskey, J, Ely, LK, Mifsud, NA, Brooks, AG, Kjer-Nielsen, L, Kostenko, L, Rossjohn, J

Proc Natl Acad Sci U S A 2004
16551255 How TCRs bind MHCs, peptides, and coreceptors

Stanfield, RL, Rudolph, MG, Wilson, IA

Annu Rev Immunol 2006
15534202 Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment

Arnett, KL, Wiley, DC, Harrison, SC

Proc Natl Acad Sci U S A 2004
Orthologous Events
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