VCAM1 binds Integrin alpha4beta1

Stable Identifier
R-HSA-198941
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons. VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.
Literature References
PubMed ID Title Journal Year
7531291 Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.

Clements, JM, Harlos, K, Jones, EY, Dudgeon, TJ, Bottomley, MJ, Edwards, RM, Driscoll, PC, Stuart, DI, Robinson, RC

Nature 1995
11857637 Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases

Yusuf-Makagiansar, H, Murray, JS, Siahaan, TJ, Anderson, ME, Yakovleva, TV

Med Res Rev 2002
Participants
Participates
This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!