Reactome | VCAM1 binds Integrin alpha4beta1

VCAM1 binds Integrin alpha4beta1

Stable Identifier

R-HSA-198941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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Integrins play a central role in mediating lymphocyte adhesion to a number of surfaces. Integrin alphaLbeta2 (LFA-1) interacts with Intercellular adhesion molecule (ICAM)1-5, which are typically expressed on other immune system cells. ICAM4 and 5 are known to be expressed on telencepahlic neurons. VCAM-1 regulates lymphocyte adhesion to activated endothelial cells via Very Late Antigen-4 (VLA-4). To function in a circulating mode, leukocytes express LFA-1 and VLA-4 in a low ligand binding capacity. When leukocytes reach sites of imflammation, these integrins are switched to a higher binding state to guide the complex process of transmigration, tethering, rolling, arrest, adhesion and shape change. Signal cascades between LFA-1 and VLA-4 may cross-talk affecting binding affinities in a reciprocal fashion.

Literature References

PubMed ID	Title	Journal	Year
11857637	Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases Yusuf-Makagiansar, H, Anderson, ME, Yakovleva, TV, Murray, JS, Siahaan, TJ	Med Res Rev	2002
7531291	Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution. Jones, EY, Harlos, K, Bottomley, MJ, Robinson, RC, Driscoll, PC, Edwards, RM, Clements, JM, Dudgeon, TJ, Stuart, DI	Nature	1995