Reactome | CYB5A:heme reduces Asc.- to AscH-

CYB5A:heme reduces Asc.- to AscH-

Stable Identifier

R-HSA-198845

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

Synonyms

Reduction of semidehydroascorbate to ascorbate

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The reduction of cytosolic semidehydroascorbate (SDA) to ascorbate (AscH-) is catalyzed by cytochrome B5 (CYB5A) associated with the mitochondrial outer membrane. In the course of the reaction, the heme iron of the cytochrome is oxidized (Linster & Van Schaftingen 2007, Shirabe et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7668255	A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia Shirabe, K, Landi, MT, Takeshita, M, Uziel, G, Fedrizzi, E, Borgese, N	Am J Hum Genet	1995