The reduction of cytosolic semidehydroascorbate (SDA) to ascorbate (AscH-) is catalyzed by cytochrome B5 (CYB5A) associated with the mitochondrial outer membrane. In the course of the reaction, the heme iron of the cytochrome is oxidized (Linster & Van Schaftingen 2007, Shirabe et al. 1995).
Landi, MT, Borgese, N, Fedrizzi, E, Takeshita, M, Shirabe, K, Uziel, G
aldo-keto reductase (NADP) activity of CYB5A:heme [mitochondrial outer membrane]
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