Reactome | Galactosylation of collagen propeptide hydroxylysines by PLOD3

Galactosylation of collagen propeptide hydroxylysines by PLOD3

Stable Identifier

R-HSA-1981128

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, endoplasmic reticulum lumen

ReviewStatus

5/5

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Galactosylation of collagen propeptide hydroxylysines by PLOD3

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The ER membrane-associated enzyme PLOD3 has collagen galactosyltransferase activity (Heikkinen et al. 2000, Wang et al. 2002) though the biological significance of this has been questioned (Schegg et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
12475640	The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro Myllylä, R, Luosujärvi, H, Uitto, L, Wang, C, Risteli, M, Heikkinen, J	Matrix Biol	2002
10934207	Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity Myllylä, R, Wang, C, Risteli, M, Rossi, M, Heikkinen, J, Valtavaara, M, Latvala, J	J Biol Chem	2000