Reactome | p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol]

Stable Identifier

R-HSA-195297

Type

Complex

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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General

In this complex Axin is bound to beta-catenin.

Participants

components

Participates

as an output of

Phosphorylation of APC component of the destruction complex (Homo sapiens)

as an input of

Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)

as a component of

RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)

Inferred To

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Bos taurus)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Caenorhabditis elegans)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Canis familiaris)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Drosophila melanogaster)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Gallus gallus)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Mus musculus)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)

p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Sus scrofa)

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