Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGEF18 [cytosol]
Stable Identifier
R-HSA-195104
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 18, p114/Arhgef18, p114RhoGEF
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF18 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF18 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF18 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF18 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZSZ5 ARHGEF18
Gene Names
ARHGEF18, KIAA0521
Chain
chain:1-1361
Reference Genes
BioGPS Gene:23370 ARHGEF18
COSMIC (genes):ARHGEF18 ARHGEF18
CTD Gene:23370 ARHGEF18
dbSNP Gene:23370 ARHGEF18
ENSEMBL:ENSG00000104880 ARHGEF18
HGNC:17090 ARHGEF18
KEGG:hsa:23370 ARHGEF18
Monarch:23370 ARHGEF18
NCBI Gene:23370 ARHGEF18
OMIM:616432 ARHGEF18
UCSC:Q6ZSZ5 ARHGEF18
Reference Transcript
RefSeq:XM_011527839.2 ARHGEF18
RefSeq:NM_001130955.1 ARHGEF18
RefSeq:NM_015318.3 ARHGEF18
RefSeq:XM_011527838.2 ARHGEF18
RefSeq:XM_006722705.3 ARHGEF18
RefSeq:XM_011527840.1 ARHGEF18
RefSeq:XM_006722708.2 ARHGEF18
RefSeq:XM_006722706.3 ARHGEF18
Other Identifiers
11720554_a_at
16857567
17121938
213039_PM_at
213039_at
23370
36537_at
3818733
3818734
3818735
3818740
3818741
3818742
3818743
3818745
3818746
3818748
3818749
3818751
3818756
3818757
3818758
3818775
3818776
3818777
3818778
3818779
3818780
3818781
3818783
3818784
3818786
3818790
3818791
3818792
3818793
3818795
3818796
3818799
3818800
3818801
3818802
3818803
3818804
3818805
3818806
3818807
3818808
3818809
3818810
3818811
3818812
3818813
3818814
8025142
A_14_P111220
A_21_P0011667
A_23_P50357
A_33_P3378915
GE53253
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0007010
GO:0007264
GO:0008360
GO:0016324
GO:0030036
GO:0030054
GO:0035023
GO:0043226
GO:0045177
GO:0046872
GO:0051497
GO:0070062
GO:0098772
GO:0150105
HMNXSV003043965
Hs.6150.0.S1_3p_at
ILMN_1664016
PH_hs_0000626
PH_hs_0033000
TC19000125.hg
TC19001956.hg
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
GEFs [cytosol] (Homo sapiens)
Other forms of this molecule
ARHGEF18 [cell junction]
Inferred To
gxcN [cytosol]
(Dictyostelium discoideum)
ARHGEF18 [cytosol]
(Bos taurus)
ARHGEF18 [cytosol]
(Sus scrofa)
Arhgef18 [cytosol]
(Mus musculus)
arhgef18a [cytosol]
(Danio rerio)
rhgf-3 [cytosol]
(Caenorhabditis elegans)
cyst [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
XP_006722771.1
,
NP_056133.2
,
XP_011526140.1
,
XP_011526142.1
,
XP_011526141.1
,
XP_006722768.1
,
XP_006722769.1
,
NP_001124427.1
ENSEMBL
ENST00000617428
,
ENSP00000499655
,
ENSP00000470729
,
ENSP00000482647
,
ENST00000594665
,
ENST00000668164
OpenTargets
ENSG00000104880
HPA
ENSG00000104880-ARHGEF18
PRO
Q6ZSZ5
Pharos - Targets
Q6ZSZ5
HMDB Protein
HMDBP11472
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text