Reactome | Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone

Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone

Stable Identifier

R-HSA-193961

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone. This reaction is catalyzed by the isomerase activity of 3 beta-HSD, associated with the endoplasmic reticulum membrane. The active form of the enzyme is a homodimer. The enzyme occurs in two isoforms that are similar in their biochemical properties but differ in their tissue expression: type I (HSD3B1) is found in placenta and skin, while type II (HSD3B2) is found in the adrenal glands and gonads.

Literature References

PubMed ID	Title	Journal	Year
2243100	Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells Simard, J, de Launoit, Y, Lachance, Y, Luu-The, V, Labrie, F, Leblanc, G, Dumont, M, Labrie, C, Guerin, S	J Biol Chem	1990