Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone

Stable Identifier
R-HSA-193961
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone. This reaction is catalyzed by the isomerase activity of 3 beta-HSD, associated with the endoplasmic reticulum membrane. The active form of the enzyme is a homodimer. The enzyme occurs in two isoforms that are similar in their biochemical properties but differ in their tissue expression: type I (HSD3B1) is found in placenta and skin, while type II (HSD3B2) is found in the adrenal glands and gonads.

Literature References
PubMed ID Title Journal Year
2243100 Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

Lachance, Y, Luu-The, V, Labrie, C, Simard, J, Dumont, M, de Launoit, Y, Guerin, S, Leblanc, G, Labrie, F

J Biol Chem 1990
Participants
Participates
Catalyst Activity

steroid delta-isomerase activity of HSD2B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]

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