Influx of 27-hydroxycholesterol

Stable Identifier
Reaction [transition]
Homo sapiens
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27-hydroxycholesterol is transported from the extracellular space to the endoplasmic reticulum. In humans, this event is the means by which the molecule, generated from cholesterol in the brain, is taken up by liver cells for conversion to bile acids and bile salts (Babiker et al. 1999; Bjorkhem et al. 1994). While transport proteins are likely to play a role in this process, these proteins have not been identified.

Literature References
PubMed ID Title Journal Year
9717719 Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Lutjohann, D, Bjorkhem, I, Diczfalusy, U, Stahle, L, Ahlborg, G, Wahren, J

J Lipid Res 1998
8790411 Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Siden, A, Lutjohann, D, Bjorkhem, I, Diczfalusy, U, Nennesmo, I, Ahlborg, G, Breuer, O

Proc Natl Acad Sci U S A 1996
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