Influx of 24-hydroxycholesterol

Stable Identifier
R-HSA-193767
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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24-hydroxycholesterol is transported from the extracellular space to the endoplasmic reticulum. In humans, this event is the means by which the molecule, generated from cholesterol in the brain, is taken up by liver cells for conversion to bile acids and bile salts. While transport proteins are likely to play a role in this process, these proteins have not been identified (Lutjohann et al. 1996; Bjorkhem et al. 1998).

Literature References
PubMed ID Title Journal Year
8790411 Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

Lutjohann, D, Breuer, O, Ahlborg, G, Nennesmo, I, Siden, A, Diczfalusy, U, Bjorkhem, I

Proc Natl Acad Sci U S A 1996
9717719 Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

Bjorkhem, I, Lutjohann, D, Diczfalusy, U, Stahle, L, Ahlborg, G, Wahren, J

J Lipid Res 1998
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