Reactome | 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

Stable Identifier

R-HSA-193753

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, peroxisomal matrix

Synonyms

3,7,24THCA-CoA [ cytosol] => 3,7,24THCA-CoA [peroxisome]

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
        
        3,7,24THCA-CoA is translocated from the cytosol to the peroxisome (Homo sapiens)

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3,7,24THCA-CoA is translocated from the cytosol to the peroxisome

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3,7,24THCA-CoA is transported from the cytosol into the peroxisome, in an ATP-dependent process mediated by an unknown transport protein in the peroxisomal membrane (Russell 2003; Une et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12966071	ATP-dependent transport of bile acid intermediates across rat liver peroxisomal membranes Une, M, Iguchi, Y, Sakamoto, T, Tomita, T, Suzuki, Y, Morita, M, Imanaka, T	J Biochem (Tokyo)	2003
12543708	The enzymes, regulation, and genetics of bile acid synthesis Russell, DW	Annu Rev Biochem	2003