Reactome | p75NTR and RHOA-GDI interact

p75NTR and RHOA-GDI interact

Stable Identifier

R-HSA-193668

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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p75NTR directly complexes with RHO-GDI (RHO-GDP Dissociation Inhibitor). RHO-GDI inhibits the dissociation of GDP and the subsequent binding of GTP to RHOA, thus preventing formation of active RHOA. Once bound to p75NTR, RHOA-GDI is less active. p75NTR acts on RHOB in a similar mechanism.

Literature References

PubMed ID	Title	Journal	Year
9195882	A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm Moody, PC, Lian, LY, Badii, R, Barnes, M, Barsukov, I, Segal, AW, Keep, NH, Roberts, GC	Structure	1997
12692556	The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI Yamashita, T, Tohyama, M	Nat Neurosci	2003