Reactome | Hydrolysis of choloyl-CoA to cholate and CoASH

Hydrolysis of choloyl-CoA to cholate and CoASH

Stable Identifier

R-HSA-193385

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
        
        Hydrolysis of choloyl-CoA to cholate and CoASH (Homo sapiens)

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Hydrolysis of choloyl-CoA to cholate and CoASH

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The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).

Literature References

PubMed ID	Title	Journal	Year
11673457	Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism Hunt, MC, Solaas, K, Kase, BF, Alexson, SE	J Biol Chem	2002
10092594	Identification of peroxisomal acyl-CoA thioesterases in yeast and humans Jones, JM, Nau, K, Geraghty, MT, Erdmann, R, Gould, SJ	J Biol Chem	1999