Hydrolysis of choloyl-CoA to cholate and CoASH

Stable Identifier
R-HSA-193385
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).

Literature References
PubMed ID Title Journal Year
10092594 Identification of peroxisomal acyl-CoA thioesterases in yeast and humans

Jones, JM, Nau, K, Geraghty, MT, Erdmann, R, Gould, SJ

J Biol Chem 1999
11673457 Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism

Hunt, MC, Solaas, K, Kase, BF, Alexson, SE

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CoA hydrolase activity of ACOT8 [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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