The peroxisomal matrix enzyme acyl-coenzyme A thioesterase 8 (ACOT8) mediates the hydrolysis of choloyl-CoA to form cholate and CoASH (Jones et al. 1999, Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003).
Kase, BF, Alexson, SE, Solaas, K, Hunt, MC
Jones, JM, Geraghty, MT, Erdmann, R, Gould, SJ, Nau, K
CoA hydrolase activity of ACOT8 [peroxisomal matrix]
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