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CYP7A1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-192169
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 7A1, CP7A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
CYP7A1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22680 CYP7A1
Gene Names
CYP7A1, CYP7
Chain
chain:1-504
Reference Genes
BioGPS Gene:1581 CYP7A1
COSMIC (genes):CYP7A1 CYP7A1
CTD Gene:1581 CYP7A1
dbSNP Gene:1581 CYP7A1
ENSEMBL:ENSG00000167910 CYP7A1
ENSEMBL_homo_sapiens_GENE:ENSG00000167910.4 CYP7A1
HGNC:2651 CYP7A1
KEGG Gene (Homo sapiens):1581 CYP7A1
Monarch:1581 CYP7A1
NCBI Gene:1581 CYP7A1
OMIM:118455 CYP7A1
UCSC:P22680 CYP7A1
Reference Transcript
RefSeq:NM_000780.3 CYP7A1
Other Identifiers
11737278_at
11737279_at
1581
17077442
207406_PM_at
207406_at
3136757
3136758
3136759
3136760
3136761
3136763
3136764
3136765
3136766
3136767
31926_at
8150920
A_23_P146198
GE58149
GO:0003824
GO:0004497
GO:0005506
GO:0005783
GO:0005789
GO:0006629
GO:0006699
GO:0006707
GO:0008123
GO:0008202
GO:0008203
GO:0014070
GO:0015721
GO:0016020
GO:0016125
GO:0016491
GO:0016705
GO:0016709
GO:0020037
GO:0023052
GO:0032966
GO:0033782
GO:0038183
GO:0042632
GO:0043226
GO:0043231
GO:0045471
GO:0045542
GO:0045717
GO:0046872
GO:0070857
GO:0071333
GO:0071397
HMNXSV003046164
ILMN_1749575
PH_hs_0027534
TC08001245.hg
X56088_s_at
g13787185_3p_at
Participates
as an output of
Expression of CYP7A1 (Homo sapiens)
as a member of
Cytochrome P450 (CYP7A1 based) [endoplasmic reticulum membrane] (Homo sapiens)
as a candidate of
Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
CYP7A1 [endoplasmic reticulum membrane]
(Bos taurus)
CYP7A1 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP7A1 [endoplasmic reticulum membrane]
(Gallus gallus)
CYP7A1 [endoplasmic reticulum membrane]
(Mus musculus)
CYP7A1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP7A1 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP7A1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000771.2
Guide to Pharmacology - Targets
1354
OpenTargets
ENSG00000167910
HPA
ENSG00000167910-CYP7A1
GeneCards
P22680
Ensembl
ENSG00000167910
,
ENST00000301645
,
ENSP00000301645
PRO
P22680
Pharos - Targets
P22680
Orphanet
18731
HMDB Protein
HMDBP00502
PDB
3DAX
,
3SN5
,
3V8D
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