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Internalization of gap junction plaques
Stable Identifier
R-HSA-190519
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
GJ plaques, clusters of GJ channels, can be internalized to form large, double-membrane vesicles (aka AGJs). Internalized AGJ vesicles subdivide into smaller vesicles that are subsequently degraded by endo/lysosomal pathways (Piehl et al., 2007).
Literature References
PubMed ID
Title
Journal
Year
17108328
Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process
Gumpert, A
,
Segretain, D
,
Falk, MM
,
Piehl, M
,
Denizot, JP
,
Lehmann, C
Mol Biol Cell
2007
Participants
Input
MYO6 [plasma membrane]
(Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane]
(Homo sapiens)
Output
Invaginating gap junction plaques [lysosomal membrane]
(Homo sapiens)
Participates
as an event of
Gap junction degradation (Homo sapiens)
Orthologous Events
Internalization of gap junction plaques (Bos taurus)
Internalization of gap junction plaques (Caenorhabditis elegans)
Internalization of gap junction plaques (Canis familiaris)
Internalization of gap junction plaques (Drosophila melanogaster)
Internalization of gap junction plaques (Gallus gallus)
Internalization of gap junction plaques (Mus musculus)
Internalization of gap junction plaques (Rattus norvegicus)
Internalization of gap junction plaques (Sus scrofa)
Authored
Gilleron, J (2007-01-03)
Segretain, D (2007-01-03)
Falk, MM (2007-01-03)
Reviewed
Falk, MM (2007-02-02)
Created
Matthews, L (2007-01-09)
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