FGFR2b binds to FGF

Stable Identifier
R-HSA-190260
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.

Literature References
PubMed ID Title Journal Year
1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors

Dionne, CA, Crumley, G, Bellot, F, Kaplow, JM, Searfoss, G, Ruta, M, Burgess, WH, Jaye, M, Schlessinger, J

EMBO J 1990
15863029 Structural basis for fibroblast growth factor receptor activation

Mohammadi, M, Olsen, SK, Ibrahimi, OA

Cytokine Growth Factor Rev 2005
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Zhang, X, Ibrahimi, OA, Olsen, SK, Umemori, H, Mohammadi, M, Ornitz, DM

J Biol Chem 2006
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This event is regulated
Orthologous Events
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