Reactome | FGFR2b binds to FGF

FGFR2b binds to FGF

Stable Identifier

R-HSA-190260

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - FGFR2 ligand binding and activation (Homo sapiens)
        
        FGFR2b ligand binding and activation (Homo sapiens)
        
        FGFR2b binds to FGF (Homo sapiens)

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In this reaction, FGF receptor 2b in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.

Literature References

PubMed ID	Title	Journal	Year
15863029	Structural basis for fibroblast growth factor receptor activation Mohammadi, M, Olsen, SK, Ibrahimi, OA	Cytokine Growth Factor Rev	2005
1697263	Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors Dionne, CA, Crumley, G, Bellot, F, Kaplow, JM, Searfoss, G, Ruta, M, Burgess, WH, Jaye, M, Schlessinger, J	EMBO J	1990
16597617	Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Zhang, X, Ibrahimi, OA, Olsen, SK, Umemori, H, Mohammadi, M, Ornitz, DM	J Biol Chem	2006