Reactome | Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

Stable Identifier

R-HSA-188467

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

ReviewStatus

5/5

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Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

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FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.

Literature References

PubMed ID	Title	Journal	Year
7821823	The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA Lehn, DA, Brown, LJ, Simonson, GD, Moran, SM, MacDonald, MJ	Gene	1994
8163052	Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients Fernandez-Alvarez, J, Conget, I, Rasschaert, J, Sener, A, Gomis, R, Malaisse, WJ	Diabetologia	1994
8687421	Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene Matsutani, A, Takeuchi, Y, Ishihara, H, Kuwano, S, Oka, Y	Biochem Biophys Res Commun	1996
	Biochemistry, 4th ed Stryer, L		1995