Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)

Stable Identifier
R-HSA-188467
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FAD-linked mitochondrial glycerol 3-phosphate dehydrogenase (GPD2, alias: mGPDH) and its NAD-linked cytosolic isoform (GPD1, alias:cGPDH) constitute glycerol phosphate shuttle. GPD2 catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Impaired activity of GPD2 has been suggested to be one of the primary causes of insulin secretory defects in beta-cells and thus it is a candidate gene for type 2 diabetes.
Literature References
PubMed ID Title Journal Year
7821823 The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA

Moran, SM, MacDonald, MJ, Brown, LJ, Simonson, GD, Lehn, DA

Gene 1994
8163052 Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients

Sener, A, Rasschaert, J, Gomis, R, Fernandez-Alvarez, J, Malaisse, WJ, Conget, I

Diabetologia 1994
8687421 Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene

Kuwano, S, Takeuchi, Y, Ishihara, H, Matsutani, A, Oka, Y

Biochem Biophys Res Commun 1996
  Biochemistry, 4th ed

Stryer, L

  1995
Participants
Participates
Event Information
Go Biological Process
Catalyst Activity

glycerol-3-phosphate dehydrogenase (quinone) activity of GPD2 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!