CDC42:GTP binds CBL:Beta-Pix

Stable Identifier
R-HSA-183094
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CDC42 lures CBL away from the receptor
ReviewStatus
5/5
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CDC42:GTP binds CBL:Beta-Pix
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Activated CDC42 binds to Beta-Pix (p85Cool-1), a protein that directly associates with CBL. This inhibits the binding of CBL to the EGF receptor and thus prevents CBL from catalyzing receptor ubiquitination.

Literature References
PubMed ID Title Journal Year
14505571 Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation

Wu, WJ, Tu, S, Cerione, RA

Cell 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
CDC42:GTP binds CBL:Beta-Pix (Bos taurus)
CDC42:GTP binds CBL:Beta-Pix (Caenorhabditis elegans)
CDC42:GTP binds CBL:Beta-Pix (Canis familiaris)
CDC42:GTP binds CBL:Beta-Pix (Danio rerio)
CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
CDC42:GTP binds CBL:Beta-Pix (Gallus gallus)
CDC42:GTP binds CBL:Beta-Pix (Mus musculus)
CDC42:GTP binds CBL:Beta-Pix (Rattus norvegicus)
CDC42:GTP binds CBL:Beta-Pix (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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