Binding of CBL to EGFR

Stable Identifier
R-HSA-183055
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Binding of CBL to EGFR
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Phosphorylation at tyrosine Y1069 (i.e. Y1045 in the mature protein) of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor.
Literature References
PubMed ID Title Journal Year
15475003 Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

Grovdal, LM, Madshus, IH, Stang, E, Sorkin, A

Exp Cell Res 2004
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Orthologous Events
Binding of CBL to EGFR (Bos taurus)
Binding of CBL to EGFR (Caenorhabditis elegans)
Binding of CBL to EGFR (Canis familiaris)
Binding of CBL to EGFR (Danio rerio)
Binding of CBL to EGFR (Drosophila melanogaster)
Binding of CBL to EGFR (Gallus gallus)
Binding of CBL to EGFR (Mus musculus)
Binding of CBL to EGFR (Rattus norvegicus)
Binding of CBL to EGFR (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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