Phosphorylation at tyrosine Y1069 (i.e. Y1045 in the mature protein) of EGFR creates a major docking site for E3 ubiquitin-protein ligase, CBL (Casitas B-lineage lymphoma proto- oncogene) and is required to sort the EGFR to lysosomes for degradation. The E3 ligase CBL plays a crucial role in these events as it dually participates in early events of internalization via a CIN85-endophilin dependent mechanism and endocytic sorting by mediating multiple monoubiquitylation of the receptor.
Grovdal, LM, Madshus, IH, Stang, E, Sorkin, A
© 2023 Reactome
