Reactome | Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

Stable Identifier

R-HSA-183002

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

Beta-Pix pushes CIN85 away from CBL

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Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85

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High concentrations of active CDC42 (bound to GTP) and Beta-Pix may promote the binding of Beta-Pix to CBL, pushing out the usually preferred binding partner CIN85 (SH3KBP1) from the CBL complex. This competitive mechanism could block the CIN85-imposed clustering phenomenon on CBL that is required for tighter binding (Schmidt et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16407834	Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix Schmidt, MH, Husnjak, K, Szymkiewicz, I, Haglund, K, Dikic, I	Oncogene	2006