Assembly of EGFR complex in clathrin-coated vesicles

Stable Identifier
R-HSA-182994
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Assembly of EGFR complex in clathrin-coated vesicles
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CBL-CIN85-Endophilin complex mediates ligand-induced down-regulation of the EGF receptor. The BAR domain of endophilin induces membrane curvature. The three SH3 domains of CIN85 bind to atypical proline-arginine motifs (PxxxPR) present in the carboxyl termini of CBL and CBL-b. In this way, CIN85 clusters CBL molecules, which is crucial for efficient EGFR endocytosis and degradation (Soubeyran et al. 2002).
Literature References
PubMed ID Title Journal Year
11894095 Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

Szymkiewicz, I, Soubeyran, P, Langdon, WY, Kowanetz, K, Dikic, I

Nature 2002
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Orthologous Events
Assembly of EGFR complex in clathrin-coated vesicles (Bos taurus)
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Assembly of EGFR complex in clathrin-coated vesicles (Canis familiaris)
Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)
Assembly of EGFR complex in clathrin-coated vesicles (Gallus gallus)
Assembly of EGFR complex in clathrin-coated vesicles (Mus musculus)
Assembly of EGFR complex in clathrin-coated vesicles (Rattus norvegicus)
Assembly of EGFR complex in clathrin-coated vesicles (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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