Sprouty lures CBL away from EGFR

Stable Identifier
R-HSA-182988
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Sprouty lures CBL away from EGFR
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The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation.
Literature References
PubMed ID Title Journal Year
12234920 Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

Yusoff, P, Fong, CW, Langdon, WY, Low, BC, Wong, ES, Lim, J, Guy, GR

EMBO J 2002
12593795 Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

Litvak, V, Lev, S, Zwang, Y, Yarden, Y, Medvedovsky, H, Rubin, C

Curr Biol 2003
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Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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