Reactome | Sprouty lures CBL away from EGFR

Sprouty lures CBL away from EGFR

Stable Identifier

R-HSA-182988

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation.

Literature References

PubMed ID	Title	Journal	Year
12234920	Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling Wong, ES, Fong, CW, Lim, J, Yusoff, P, Low, BC, Langdon, WY, Guy, GR	EMBO J	2002
12593795	Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops Rubin, C, Litvak, V, Medvedovsky, H, Zwang, Y, Lev, S, Yarden, Y	Curr Biol	2003