Reactome | Translocation of Rev:importin-beta:B23 to the nucleus

Translocation of Rev:importin-beta:B23 to the nucleus

Stable Identifier

R-HSA-180732

Type

Reaction [dissociation]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm, nuclear envelope

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        Interactions of Rev with host cellular proteins (Homo sapiens)
        
        Nuclear import of Rev protein (Homo sapiens)
        
        Translocation of Rev:importin-beta:B23 to the nucleus (Homo sapiens)

General

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SVG | | PPTX | SBGN

Translocation of Rev:importin-beta:B23 to the nucleus

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Following the association of Rev with importin-beta, the Rev:B23:importin-beta complex is imported into the nucleus.

Literature References

PubMed ID	Title	Journal	Year
9092824	Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin Mehrotra, B, Wingfield, PT, Baumann, A, Szebeni, A, Olson, MO, Adam, SA	Biochemistry	1997
9405152	Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta Henderson, BR, Percipalle, P	J Mol Biol	1997