Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand

Stable Identifier
R-HSA-180632
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3' end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5' to 3' regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)

Literature References
PubMed ID Title Journal Year
12808465 The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Zhang, H, Yang, B, Pomerantz, RJ, Zhang, C, Arunachalam, SC, Gao, L

Nature 2003
15098018 Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome

Yu, Q, Konig, R, Pillai, S, Chiles, K, Kearney, M, Palmer, S, Richman, D, Coffin, JM, Landau, NR

Nat Struct Mol Biol 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dCTP deaminase activity of APOBEC3G [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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