Interaction of Vpr with importin alpha

Stable Identifier
R-HSA-180627
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
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Interaction of Vpr with importin alpha
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Vpr interacts with importin-alpha through alphaH1 and alphaH2. The interaction via alphaH1 is indispensable for the nuclear entry of Vpr (Kamata et al., 2005) .

Literature References
PubMed ID Title Journal Year
9582382 Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex

Popov, S, Rexach, M, Ratner, L, Blobel, G, Bukrinsky, M

J Biol Chem 1998
9436978 HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection

Vodicka, MA, Koepp, DM, Silver, PA, Emerman, M

Genes Dev 1998
15731250 Importin-alpha promotes passage through the nuclear pore complex of human immunodeficiency virus type 1 Vpr

Kamata, M, Nitahara-Kasahara, Y, Miyamoto, Y, Yoneda, Y, Aida, Y

J Virol 2005
Participants
Input
Output
Participant Of
hasEvent
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Matthews, L  (2006-05-15)
Reviewed
Zhao, RY  (2006-07-12)
Created
Matthews, L  (2006-05-23)