The Vpu:CD4:beta-TrCP complex recruits SKP1

Stable Identifier
R-HSA-180599
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The Vpu:CD4:beta-TrCP complex recruits SKP1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SKP1 component of the SCF complex is recruited to the Vpu:beta-TrCP:CD4 complex.

Literature References
PubMed ID Title Journal Year
9660940 A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

Margottin, F, Richard, V, Benarous, R, Durand, H, Selig, L, Strebel, K, Bour, SP, Thomas, D, Benichou, S

Mol Cell 1998
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2006-05-15)
Reviewed
Benarous, R  (2006-09-21)
Created
Matthews, L  (2006-05-23)
Cite Us!