Association of APOBEC3G:Vif with the Cul5-SCF complex

Stable Identifier
R-HSA-180555
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
ReviewStatus
5/5
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The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5.
Literature References
PubMed ID Title Journal Year
14564014 Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex

Yu, XF, Luo, K, Kong, W, Mao, P, Liu, B, Yu, X, Yu, Y

Science 2003
Participants
Participates
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Reviewed
Created
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