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Association of APOBEC3G:Vif with the Cul5-SCF complex
Stable Identifier
R-HSA-180555
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Association of APOBEC3G:Vif with the Cul5-SCF complex (Homo sapiens)
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The interaction between Vif and the E3 ubiquitin ligase complex (Cullin5, Elongin B and Elongin C, and Rbx1) takes place through direct binding of the SOCS box motif in the viral protein Vif to the host protein Elongin C. Moreover, a conserved HCCH motif in Vif allows binding to Cullin 5.
Literature References
PubMed ID
Title
Journal
Year
14564014
Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex
Yu, XF
,
Luo, K
,
Kong, W
,
Mao, P
,
Liu, B
,
Yu, X
,
Yu, Y
Science
2003
Participants
Input
Cul5-SCF complex [cytosol]
(Homo sapiens)
Vif:APOBEC3G complex [cytosol]
(Homo sapiens)
Output
APOBEC3G:Vif:Cul5:SCF complex [cytosol]
(Homo sapiens)
Participates
as an event of
Vif-mediated degradation of APOBEC3G (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2006-05-16)
Reviewed
Mulder, L (2007-01-31)
Simon, V (2007-01-31)
Created
Matthews, L (2006-05-23)
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