Conjugation of salicylate with glycine

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R-HSA-177128
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Homo sapiens
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In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylate (ST). ST can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here. It is the major route of ST catabolism and accounts for 20–65% of the products (Hutt et al, 1986). The conjugation proceeds in two steps. First, ST and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, ST-CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994).

Literature References
PubMed ID Title Journal Year
7802672 Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver

Qureshi, IA, Mawal, YR

Biochem Biophys Res Commun 1994
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Kelley, M, Warren, RS, Lau, E, Vessey, DA

J Biochem Mol Toxicol 2003
3705620 The metabolism of aspirin in man: a population study

Smith, RL, Caldwell, J, Hutt, AJ

Xenobiotica 1986
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