Multiple proteins are localized at replication fork

Stable Identifier
R-HSA-176942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Multiple proteins are localized at replication fork
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By applying the chromatin immunoprecipitation technique to paused forks, certain proteins like DNA pol alpha, DNA pol delta, DNA pol epsilon, MCM2-7, CDC45, GINS and MCM10 were identified. By uncoupling a helicase at the site using a polymerase inhibitor, MCM2-7, GINS complex and CDC45 alone were found to be enriched at the paused fork suggesting these proteins may form a part of an "unwindosome" at the replicating fork.
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Inferred From
Multiple Xenopus proteins are localized at replication fork (Xenopus laevis)
Authored
Tye, BK  (2006-03-17)
Created
Gopinathrao, G  (2006-03-18)
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