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Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Stable Identifier
R-HSA-176814
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
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APC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein Cdc20. APC/C:Cdc20 promotes the multiubiquitination and ordered degradation of Cyclin A and Nek2 degradation in prometaphase followed by Cyclin B and securin in metaphase (Reviewed in Castro et al., 2005).
Literature References
PubMed ID
Title
Journal
Year
15678131
The anaphase-promoting complex: a key factor in the regulation of cell cycle
Lorca, T
,
Bernis, C
,
Vigneron, S
,
Castro, A
,
Labbe, JC
Oncogene
2005
Participants
Events
Phosphorylation of the APC/C
(Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins
(Homo sapiens)
Participates
as an event of
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Event Information
Go Biological Process
anaphase-promoting complex-dependent catabolic process (0031145)
Orthologous Events
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Dictyostelium discoideum)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Rattus norvegicus)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Xenopus tropicalis)
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-03-13)
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