SULTs transfer (SO4)2- group to 27HCHOL

Stable Identifier
R-HSA-176494
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
27-hydroxycholesterol + PAPS => 27-hydroxycholesterol 3-sulfate + PAP
ReviewStatus
5/5
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SULTs transfer (SO4)2- group to 27HCHOL
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The sulfonation of 27-hydroxycholesterol (27HCHOL) is catalyzed by both the a and b isoforms of SULT2B1 (Javitt et al. 2001).
Literature References
PubMed ID Title Journal Year
11416019 Cholesterol and hydroxycholesterol sulfotransferases: identification, distinction from dehydroepiandrosterone sulfotransferase, and differential tissue expression

Javitt, NB, Lee, YC, Shimizu, C, Fuda, H, Strott, CA

Endocrinology 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

alcohol sulfotransferase activity of SULTs active on 27HCHOL [cytosol]

Physical Entity
SULTs active on 27HCHOL [cytosol] (Homo sapiens)
Activity
alcohol sulfotransferase activity (GO:0004027)
Orthologous Events
SULTs transfer (SO4)2- group to 27HCHOL (Bos taurus)
SULTs transfer (SO4)2- group to 27HCHOL (Caenorhabditis elegans)
SULTs transfer (SO4)2- group to 27HCHOL (Canis familiaris)
SULTs transfer (SO4)2- group to 27HCHOL (Danio rerio)
SULTs transfer (SO4)2- group to 27HCHOL (Gallus gallus)
SULTs transfer (SO4)2- group to 27HCHOL (Mus musculus)
SULTs transfer (SO4)2- group to 27HCHOL (Rattus norvegicus)
SULTs transfer (SO4)2- group to 27HCHOL (Sus scrofa)
SULTs transfer (SO4)2- group to 27HCHOL (Xenopus tropicalis)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
D'Eustachio, P  (2006-03-09)
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