RPA complexed to ssDNA

Stable Identifier
R-HSA-176293
Type
Complex
Species
Homo sapiens
Compartment
Synonyms
RPA-ssDNA complex
Locations in the PathwayBrowser
Summation

RPA associates with ssDNA in distinct complexes that can be distinguished by the length of ssDNA occluded by each RPA molecule. These complexes reflect the progressive association of distinct DNA-binding domains present in the RPA heterotrimeric structure. Binding is coupled to significant conformational changes within RPA that are observable at the microscopic level. Presumably, the different conformations of free and ssDNA-bound RPA allow the protein to selectively interact with factors such as ATR-ATRIP when bound to DNA.

Participants
Participant Of
Inferred To