NAT2 acetylation

Stable Identifier
R-HSA-174967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Typical NAT 2 substrates were chosen as examples. They are paraxanthine, isoniazid and N-hydroxy 4-aminobiphenyl.

Literature References
PubMed ID Title Journal Year
8353847 Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

Hein, DW, Doll, MA, Rustan, TD, Gray, K, Feng, Y, Ferguson, RJ, Grant, DM

Carcinogenesis 1993
8068562 N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation

Hanna, PE

Adv. Pharmacol. 1994
23517104 Arylamine N-acetyltransferases: a structural perspective

Zhou, X, Ma, Z, Dong, D, Wu, B

Br. J. Pharmacol. 2013
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
arylamine N-acetyltransferase activity of AcC-NAT2 [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created
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