NAT2 acetylation

Stable Identifier
R-HSA-174967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NAT2 acetylation
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Typical NAT 2 substrates were chosen as examples. They are paraxanthine, isoniazid and N-hydroxy 4-aminobiphenyl.
Literature References
PubMed ID Title Journal Year
8068562 N-acetyltransferases, O-acetyltransferases, and N,O-acetyltransferases: enzymology and bioactivation

Hanna, PE

Adv. Pharmacol. 1994
8353847 Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

Hein, DW, Doll, MA, Rustan, TD, Gray, K, Feng, Y, Ferguson, RJ, Grant, DM

Carcinogenesis 1993
23517104 Arylamine N-acetyltransferases: a structural perspective

Zhou, X, Ma, Z, Dong, D, Wu, B

Br. J. Pharmacol. 2013
Participants
Input
Output
Participates
as an event of
Catalyst Activity

arylamine N-acetyltransferase activity of AcC-NAT2 [cytosol]

Physical Entity
AcC-NAT2 [cytosol] (Homo sapiens)
Activity
arylamine N-acetyltransferase activity (GO:0004060)
Orthologous Events
NAT2 acetylation (Bos taurus)
NAT2 acetylation (Danio rerio)
NAT2 acetylation (Gallus gallus)
NAT2 acetylation (Mus musculus)
NAT2 acetylation (Rattus norvegicus)
NAT2 acetylation (Sus scrofa)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-23)
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