chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex

Stable Identifier
R-HSA-174657
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Chylomicron micron remnants containing apolipoprotein E associate with the surfaces of cells in a process that probably involves several steps and that requires the presence (but not the catalytic activity) of heparan sulfate proteoglycan (HSPG)-associated hepatic lipase (HL). This process ultimately results in binding of the remnant to cell-surface LDL receptors (LDLR) (Ji et al. 1994). The molecular details of LDLR binding, and of the following steps of remnant endocytosis, are inferred from those of the coorresponding step of LDLR-mediated low-density lipoprotein (LDL) endocytosis. In the body, this process occurs in the liver.

Literature References
PubMed ID Title Journal Year
8300609 Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans

Ji, ZS, Fazio, S, Lee, YL, Mahley, RW

J Biol Chem 1994
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