Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1

Stable Identifier
R-HSA-174238
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

One model ( the direct inhibition model) describing the inhibition of the APC/C during the mitotic spindle checkpoint suggests that the association of the hBUBR1:hBUB3:MAD2*:CDC20 mitotic checkpoint complex (MCC) with APC/C results in the inactivation of APC/C. The affinity between MCC and APC/C is not high, thus inhibition is readily reversible when the mitotic spindle checkpoint has been satisfied.

Literature References
PubMed ID Title Journal Year
11535616 Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

Sudakin, V, Chan, GK, Yen, TJ

J Cell Biol 2001
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed