Reactome | Free APC/C phosphorylated by Cyclin B:Cdc2

Free APC/C phosphorylated by Cyclin B:Cdc2

Stable Identifier

R-HSA-174132

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        Phosphorylation of the APC/C (Homo sapiens)
        
        Free APC/C phosphorylated by Cyclin B:Cdc2 (Homo sapiens)

General

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Free APC/C phosphorylated by Cyclin B:Cdc2

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Phosphorylation of the APC/C is believed to be required for its activation. While the identity of the essential phosphorylation sites and the kinase(s) responsible are not known with certainty, in vitro studies have shown that the Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7 are phosphorylated and that the Cdk1 and Plk1 kinases may play a role.

Literature References

PubMed ID	Title	Journal	Year
14657031	Mitotic regulation of the human anaphase-promoting complex by phosphorylation Kraft, C, Herzog, F, Gieffers, C, Mechtler, K, Hagting, A, Pines, J, Peters, JM	EMBO J	2003
11859075	The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk Golan, A, Yudkovsky, Y, Hershko, A	J Biol Chem	2002