Free APC/C phosphorylated by Cyclin B:Cdc2

Stable Identifier
R-HSA-174132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of the APC/C is believed to be required for its activation. While the identity of the essential phosphorylation sites and the kinase(s) responsible are not known with certainty, in vitro studies have shown that the Apc1 and the tetratricopeptide repeat (TPR) subunits Cdc27, Cdc16, Cdc23 and Apc7 are phosphorylated and that the Cdk1 and Plk1 kinases may play a role.

Literature References
PubMed ID Title Journal Year
11859075 The cyclin-ubiquitin ligase activity of cyclosome/APC is jointly activated by protein kinases Cdk1-cyclin B and Plk

Golan, A, Yudkovsky, Y, Hershko, A

J Biol Chem 2002
14657031 Mitotic regulation of the human anaphase-promoting complex by phosphorylation

Kraft, C, Herzog, F, Gieffers, C, Mechtler, K, Hagting, A, Pines, J, Peters, JM

EMBO J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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